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Kreatina
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| Nama | |
|---|---|
| Nama IUPAC
Asid 2-[karbamimidoil(metil)amino]asetik
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| Nama lain
Asid (α-metilguanido)asetikAsid metilguanidinoasetik
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| Pengecam | |
Imej model 3D Jmol
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| ECHA InfoCard | 100.000.278 |
| Nombor EC |
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CompTox Dashboard (EPA)
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| Sifat | |
| C4H9N3O2 | |
| Jisim molar | 131.14 g·mol−1 |
| Rupa bentuk | Hablur putih |
| Bau | Tiada bau |
| Takat lebur | 255 °C (491 °F; 528 K) |
| 13.3 g L−1 (at 18 °C) | |
| log P | −1.258 |
| Keasidan (pKa) | 3.429 |
| Kebesan (pKb) | 10.568 |
| Titik isoelektrik | 8.47 |
Kecuali jika dinyatakan sebaliknya, data diberikan untuk bahan-bahan dalam keadaan piawainya (pada 25 °C [77 °F], 100 kPa). | |
| Rujukan kotak info | |
Kreatina ialah sebatian kimia dengan formula kimia (H2N)(HN)CN(CH3)CH2CO2H. Kreatina biasanya dijumpai dalam vertebrata dan berperanan dalam kitaran semula adenosina trifosfat (ATP), unit tenaga sel badan, di mana adenosina difosfat (ADP) ditukar semula menjadi ATP melalui pendermaan daripada kumpulan fosfat, terutamanya dalam sel otak dan otot. Kreatina juga bertindak sebagai sebatian penimbal.[1]
Kreatina biasanya dimakan sebagai diet tambahan utama dan dipasarkan dalam bentuk etil ester, glukonat, monohidrat dan nitrat.[2]
- ^ Barcelos RP, Stefanello ST, Mauriz JL, Gonzalez-Gallego J, Soares FA (2016). "Creatine and the Liver: Metabolism and Possible Interactions". Mini Reviews in Medicinal Chemistry. 16 (1): 12–8. doi:10.2174/1389557515666150722102613. PMID 26202197.
The process of creatine synthesis occurs in two steps, catalyzed by L-arginine:glycine amidinotransferase (AGAT) and guanidinoacetate N-methyltransferase (GAMT), which take place mainly in kidney and liver, respectively. This molecule plays an important energy/pH buffer function in tissues, and to guarantee the maintenance of its total body pool, the lost creatine must be replaced from diet or de novo synthesis.
- ^ Cooper R, Naclerio F, Allgrove J, Jimenez A (July 2012). "Creatine supplementation with specific view to exercise/sports performance: an update". Journal of the International Society of Sports Nutrition. 9 (1): 33. doi:10.1186/1550-2783-9-33. PMC 3407788. PMID 22817979.
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