MTOR

MTOR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JT6, 1AUE, 1FAP, 1NSG, 2FAP, 2GAQ, 2NPU, 2RSE, 3FAP, 4DRH, 4DRI, 4DRJ, 4FAP, 4JSN, 4JSP, 4JSV, 4JSX, 4JT5, 5FLC
Identifiers
Aliases	MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, mechanistic target of rapamycin, mechanistic target of rapamycin kinase
External IDs	OMIM: 601231; MGI: 1928394; HomoloGene: 3637; GeneCards: MTOR; OMA:MTOR - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 11,106,535 bp[1] End 11,262,551 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 78.76 cM Start 148,533,068 bp[2] End 148,642,140 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad right hemisphere of cerebellum left testis right testis gastrocnemius muscle right frontal lobe muscle of thigh testicle ventricular zone apex of heart Top expressed in spermatid spermatocyte right kidney dentate gyrus of hippocampal formation granule cell superior frontal gyrus genital tubercle primary visual cortex muscle of thigh ventricular zone neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding TFIIIC-class transcription factor complex binding kinase activity ATP binding protein serine/threonine kinase activity transferase activity ribosome binding protein binding protein kinase binding nucleotide binding phosphoprotein binding protein kinase activity protein-containing complex binding identical protein binding translation regulator activity Cellular component cytoplasm cytosol phosphatidylinositol 3-kinase complex membrane mitochondrion TORC1 complex organelle membrane protein-containing complex mitochondrial outer membrane endoplasmic reticulum TORC2 complex Golgi apparatus intracellular membrane-bounded organelle nucleoplasm soma PML body endoplasmic reticulum membrane Golgi membrane lysosomal membrane dendrite endomembrane system nucleus lysosome glutamatergic synapse postsynaptic cytosol Biological process germ cell development positive regulation of protein phosphorylation response to amino acid positive regulation of lipid biosynthetic process positive regulation of actin filament polymerization positive regulation of skeletal muscle hypertrophy positive regulation of granulosa cell proliferation regulation of carbohydrate utilization post-embryonic development positive regulation of dendritic spine development positive regulation of translation positive regulation of eating behavior protein phosphorylation mRNA stabilization cell projection organization regulation of glycogen biosynthetic process positive regulation of cell growth involved in cardiac muscle cell development positive regulation of neuron maturation positive regulation of glial cell proliferation cellular response to hypoxia negative regulation of cell size response to cocaine positive regulation of protein kinase B signaling cardiac muscle contraction maternal process involved in female pregnancy ruffle organization regulation of GTPase activity cardiac muscle cell development positive regulation of transcription of nucleolar large rRNA by RNA polymerase I regulation of membrane permeability response to insulin regulation of myelination regulation of fatty acid beta-oxidation regulation of osteoclast differentiation positive regulation of cholangiocyte proliferation regulation of protein kinase B signaling spinal cord development positive regulation of peptidyl-tyrosine phosphorylation social behavior protein autophosphorylation negative regulation of cholangiocyte apoptotic process regulation of brown fat cell differentiation regulation of protein kinase activity negative regulation of protein phosphorylation positive regulation of oligodendrocyte differentiation regulation of carbohydrate metabolic process regulation of actin cytoskeleton organization voluntary musculoskeletal movement phosphorylation multicellular organism growth negative regulation of muscle atrophy wound healing positive regulation of neurogenesis response to morphine positive regulation of sensory perception of pain protein catabolic process 'de novo' pyrimidine nucleobase biosynthetic process cellular response to nutrient levels energy reserve metabolic process peptidyl-threonine phosphorylation positive regulation of transcription by RNA polymerase III positive regulation of smooth muscle cell proliferation visual learning positive regulation of myotube differentiation positive regulation of cell death positive regulation of endothelial cell proliferation negative regulation of iodide transmembrane transport cardiac muscle tissue development positive regulation of nitric oxide biosynthetic process regulation of response to food heart morphogenesis positive regulation of neuron death cardiac cell development negative regulation of protein ubiquitination brain development positive regulation of gene expression long-term memory heart valve morphogenesis peptidyl-serine phosphorylation positive regulation of neuron projection development regulation of cellular response to heat positive regulation of lamellipodium assembly positive regulation of stress fiber assembly signal transduction regulation of protein phosphorylation negative regulation of macroautophagy anoikis TOR signaling DNA repair regulation of cell size negative regulation of autophagy positive regulation of epithelial to mesenchymal transition regulation of macroautophagy cellular response to amino acid starvation positive regulation of keratinocyte migration cellular response to amino acid stimulus cellular response to leucine positive regulation of wound healing, spreading of epidermal cells cellular response to leucine starvation cellular response to starvation TORC1 signaling growth regulation of cell growth response to nutrient activation of protein kinase B activity T-helper 1 cell lineage commitment response to activity positive regulation of phosphoprotein phosphatase activity negative regulation of calcineurin-NFAT signaling cascade regulation of translation at synapse, modulating synaptic transmission positive regulation of cytoplasmic translational initiation response to nutrient levels Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2475 56717 Ensembl ENSG00000198793 ENSMUSG00000028991 UniProt P42345 Q9JLN9 RefSeq (mRNA) NM_004958 NM_001386500 NM_001386501 NM_020009 RefSeq (protein) NP_004949 NP_064393 Location (UCSC) Chr 1: 11.11 – 11.26 Mb Chr 4: 148.53 – 148.64 Mb PubMed search [3] [4]
Wikidata
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The mammalian target of rapamycin (mTOR),^[5] also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene.^[6][7][8] mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases.^[9]

mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes.^[10] In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription.^[10][11] As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors.^[12] mTORC2 has also been implicated in the control and maintenance of the actin cytoskeleton.^[10][13]