Paratiroid hormon

Paratiroid hormon
Uygun yapılar PDB Ortolog araması: PDBe RCSB PDB kimlik kodlarının listesi 1BWX, 1ET1, 1FVY, 1HPH, 1HPY, 1HTH, 1ZWA, 1ZWB, 1ZWD, 1ZWE, 1ZWF, 1ZWG, 2L1X, 3C4M
Tanımlayıcılar
Başka adlar	PTH
Dış kimlikler	OMIM: 168450 MGI: 97799 HomoloGene: 266 GeneCards: PTH
Gen yerleşimi (İnsan) Krom. 11. Kromozom (insan)[1] Bant 11p15.3 Başlangıç 13,492,054 bç[1] Bitiş 13,496,181 bç[1]
RNA ekspresyonu deseni Daha çok ekspresyon verisi başvurusu
Gen ontolojisi Moleküler işlevi • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • hormone activity • parathyroid hormone receptor binding • type 1 parathyroid hormone receptor binding • protein N-terminus binding • receptor ligand activity • peptide hormone receptor binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein bağlanması Hücresel bileşeni • intracellular anatomical structure • extracellular region • extracellular space Biyolojik süreci • positive regulation of signal transduction • positive regulation of cell proliferation in bone marrow • positive regulation of osteoclast proliferation • response to fibroblast growth factor • hormone-mediated apoptotic signaling pathway • cAMP metabolic process • response to ethanol • response to parathyroid hormone • skeletal system development • positive regulation of ossification • response to lead ion • response to nutrient levels • G protein-coupled receptor signaling pathway • response to vitamin D • negative regulation of apoptotic process in bone marrow cell • GO:1901227 negative regulation of transcription by RNA polymerase II • cellular macromolecule biosynthetic process • cellular calcium ion homeostasis • homeostasis of number of cells within a tissue • response to cadmium ion • Rho protein signal transduction • positive regulation of glucose import • positive regulation of glycogen biosynthetic process • bone resorption • positive regulation of bone mineralization • Gen ifadesinin düzenlenmesi • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cell-cell signaling • activation of phospholipase C activity • negative regulation of chondrocyte differentiation • positive regulation of inositol phosphate biosynthetic process • negative regulation of bone mineralization involved in bone maturation • regulation of signaling receptor activity • adenylate cyclase-activating G protein-coupled receptor signaling pathway • calcium ion transport • magnesium ion homeostasis • bone mineralization • phosphate ion homeostasis • calcium ion homeostasis • negative regulation of calcium ion transport Kaynaklar:Amigo / QuickGO
Ortologlar
Türler	İnsan	Fare
Entrez	5741	19226
Ensembl	ENSG00000152266	ENSMUSG00000059077
UniProt	P01270	Q9Z0L6
RefSeq (mRNA)	NM_000315 NM_001316352	NM_020623
RefSeq (protein)	NP_000306 NP_001303281	NP_065648
Yerleşim (UCSC)	Krom. 11: 13.49 – 13.5 Mb	n/a
PubMed araması	[2]	[3]
Vikiveri
İnsan'ı Gör/Düzenle Fare'yi Gör/Düzenle

Paratiroid hormon, parathormon veya PTH, paratiroid bezi tarafından salgılanan, vücutta kalsiyum metabolizmasının düzenlenmesinde rol alan hormon.

Vücutta kalsiyum metabolizmasını ayarlayan en önemli hormondur. Bu hormon dokularda kendi reseptorüne bağlanarak işlev göstermekte, kan kalsiyum seviyesinin yükselmesine ve kan fosfor düzeyinin düşmesine neden olur. Hormonun aşırı salgılandığı durum hiperparatiroidi, az salgılandığı duruma ise hipoparatiroidi adı verilir.

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000152266 - Ensembl, May 2017
2. ^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. Arşivlenmesi gereken bağlantıya sahip kaynak şablonu içeren maddeler (link)
3. ^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. Arşivlenmesi gereken bağlantıya sahip kaynak şablonu içeren maddeler (link)