Tacalcitol

Tacalcitol
Clinical data
Other names	(1α,24R)-1,24-Dihydroxyvitamin D3
AHFS/Drugs.com	International Drug Names
Routes of; administration	Topical
ATC code	D05AX04 (WHO) ;
Identifiers
	IUPAC name (1S,3R,5Z,7E,24R)-9,10-secocholesta-5,7,10-triene-1,3,24-triol;
CAS Number	57333-96-7 ;
PubChem CID	5283734;
IUPHAR/BPS	2780;
ChemSpider	4446823 ;
UNII	C2W72OJ5ZU;
ChEBI	CHEBI:32176;
ChEMBL	ChEMBL340361 ;
CompTox Dashboard (EPA)	DTXSID90905111 ;
ECHA InfoCard	100.220.855
Chemical and physical data
Formula	C27H44O3
Molar mass	416.646 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O[C@@H]1CC(\C(=C)[C@@H](O)C1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)C)C;
	InChI InChI=1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1 ; Key:BJYLYJCXYAMOFT-RSFVBTMBSA-N ;
	(what is this?) (verify)

Tacalcitol (1,24-dihydroxyvitamin D₃) is a synthetic vitamin D₃ analog.^[1] Tacalcitol is marketed under several names, including Curatoderm and Bonalfa.

It is on the World Health Organization's List of Essential Medicines.^[2]

^ Peters DC, Balfour JA (August 1997). "Tacalcitol". Drugs. 54 (2): 265–71, discussion 272. doi:10.2165/00003495-199754020-00005. PMID 9257082. S2CID 263503145.
^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

[pmid9257082-1] Peters DC, Balfour JA (August 1997). "Tacalcitol". Drugs. 54 (2): 265–71, discussion 272. doi:10.2165/00003495-199754020-00005. PMID 9257082. S2CID 263503145.

[WHO22nd-2] World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

[1]

[2]

Clinical data

Other names	(1α,24R)-1,24-Dihydroxyvitamin D₃
AHFS/Drugs.com	International Drug Names
Routes of administration	Topical
ATC code	D05AX04 (WHO)
Identifiers
IUPAC name (1S,3R,5Z,7E,24R)-9,10-secocholesta-5,7,10-triene-1,3,24-triol
CAS Number	57333-96-7^Y
PubChem CID	5283734
IUPHAR/BPS	2780
ChemSpider	4446823^N
UNII	C2W72OJ5ZU
ChEBI	CHEBI:32176
ChEMBL	ChEMBL340361^N
CompTox Dashboard (EPA)	DTXSID90905111
ECHA InfoCard	100.220.855
Chemical and physical data
Formula	C₂₇H₄₄O₃
Molar mass	416.646 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O[C@@H]1CC(\C(=C)[C@@H](O)C1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)C)C
InChI InChI=1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1^N Key:BJYLYJCXYAMOFT-RSFVBTMBSA-N^N
^NY (what is this?) (verify)

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Tacalcitol

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