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Voriconazole
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| Clinical data | |
|---|---|
| Pronunciation | /vɒrɪˈkɒnəzoʊl/ vorr-i-KON-ə-zohl |
| Trade names | Vfend, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a605022 |
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| Routes of administration | Intravenous, by mouth |
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| Pharmacokinetic data | |
| Bioavailability | 96% (oral) |
| Protein binding | 58% |
| Metabolism | Liver: CYP2C19 (significant involvement), also CYP2C9, CYP3A4 |
| Metabolites | Voriconazole N-oxide (major; minimal antifungal activity) |
| Elimination half-life | Dose-dependent |
| Excretion | Urine (80–83%)[4] |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.157.870 |
| Chemical and physical data | |
| Formula | C16H14F3N5O |
| Molar mass | 349.317 g·mol−1 |
| 3D model (JSmol) | |
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Voriconazole, sold under the brand name Vfend among others, is an antifungal medication used to treat a number of fungal infections.[5] This includes aspergillosis, candidiasis, coccidioidomycosis, histoplasmosis, penicilliosis, and infections by Scedosporium or Fusarium.[5] It can be taken by mouth or used by injection into a vein.[5]
Common side effects include vision problems, nausea, abdominal pain, rash, headache, and seeing or hearing things that are not present.[5] Use during pregnancy may result in harm to the baby.[5] It is in the triazole family of medications.[5] It works by affecting fungal metabolism and fungal cell membranes.[5]
Voriconazole was patented in 1990 and approved for medical use in the United States in 2002.[6][7] It is on the World Health Organization's List of Essential Medicines.[8]
- ^ "Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
- ^ "Product monograph brand safety updates". Health Canada. 6 June 2024. Retrieved 8 June 2024.
- ^ "Vfend EPAR". European Medicines Agency (EMA). 19 March 2002. Retrieved 14 August 2024.
- ^ Cite error: The named reference
Vfend FDA labelwas invoked but never defined (see the help page). - ^ a b c d e f g "Voriconazole". The American Society of Health-System Pharmacists. Retrieved 8 December 2017.
- ^ Kendig EL, Wilmott RW, Chernick V (2012). Kendig and Chernick's Disorders of the Respiratory Tract in Children. Elsevier Health Sciences. p. 539. ISBN 978-1437719840.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 503. ISBN 9783527607495.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
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