STAT1

STAT1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	3WWT, 1BF5, 1YVL, 2KA6
معین‌کننده‌ها
نام‌های دیگر	STAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
شناسه‌های بیرونی	OMIM: 600555 MGI: 103063 HomoloGene: 21428 GeneCards: STAT1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱ (موش)
پایان	52,201,024 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• DNA binding; • protein homodimerization activity; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • GO:0000983 RNA polymerase II general transcription initiation factor activity; • signal transducer activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • identical protein binding; • enzyme binding; • tumor necrosis factor receptor binding; • double-stranded DNA binding; • RNA polymerase II core promoter sequence-specific DNA binding; • cadherin binding; • histone acetyltransferase binding; • GO:0031493 histone binding; • ubiquitin-like protein ligase binding; • promoter-specific chromatin binding; • sequence-specific DNA binding; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • CCR5 chemokine receptor binding; • protein phosphatase 2A binding; • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific;
ترکیبات سلولی	• سیتوپلاسم; • نوکلئوپلاسم; • هستک; • perinuclear region of cytoplasm; • هسته یاخته; • سیتوزول; • آسه; • دندریت; • GO:0009327 protein-containing complex;
فرایند زیستی	• regulation of apoptotic process; • metanephric mesenchymal cell proliferation involved in metanephros development; • GO:0009373 regulation of transcription, DNA-templated; • cellular response to interferon-beta; • GO:0044324، GO:0003256، GO:1901213، GO:0046019، GO:0046020، GO:1900094، GO:0061216، GO:0060994، GO:1902064، GO:0003258، GO:0072212 regulation of transcription by RNA polymerase II; • negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; • metanephric mesenchymal cell differentiation; • tumor necrosis factor-mediated signaling pathway; • GO:1901227 negative regulation of transcription by RNA polymerase II; • renal tubule development; • response to interferon-beta; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • transcription, DNA-templated; • negative regulation of endothelial cell proliferation; • regulation of type I interferon-mediated signaling pathway; • regulation of interferon-gamma-mediated signaling pathway; • positive regulation of mesenchymal cell proliferation; • negative regulation of metanephric nephron tubule epithelial cell differentiation; • negative regulation of angiogenesis; • negative regulation by virus of viral protein levels in host cell; • GO:0022415 viral process; • endothelial cell migration; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:0072468 ورارسانی پیام; • macrophage derived foam cell differentiation; • positive regulation of erythrocyte differentiation; • type I interferon signaling pathway; • cellular response to interferon-gamma; • positive regulation of defense response to virus by host; • positive regulation of interferon-alpha production; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • defense response to virus; • interferon-gamma-mediated signaling pathway; • receptor signaling pathway via JAK-STAT; • response to nutrient; • blood circulation; • positive regulation of cell population proliferation; • response to mechanical stimulus; • GO:1904578 response to organic cyclic compound; • cellular response to insulin stimulus; • response to cytokine; • response to hydrogen peroxide; • response to peptide hormone; • positive regulation of smooth muscle cell proliferation; • response to cAMP; • positive regulation of nitric-oxide synthase biosynthetic process; • cellular response to cytokine stimulus; • GO:1904579 cellular response to organic cyclic compound; • positive regulation of transcription of Notch receptor target; • cytokine-mediated signaling pathway; • interleukin-21-mediated signaling pathway; • interleukin-6-mediated signaling pathway; • interleukin-27-mediated signaling pathway; • interleukin-35-mediated signaling pathway; • interleukin-9-mediated signaling pathway; • defense response; • regulation of cell population proliferation;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	6772
	20846
	ENSG00000115415
	ENSMUSG00000026104
	P42224
	P42225
	NM_007315، NM_139266، XM_017004783، XR_001738914، XR_001738915 XM_006712718، NM_007315، NM_139266، XM_017004783، XR_001738914، XR_001738915
	NM_001205314، NM_009283، XM_017319463، XM_017319464، NM_001357627، XM_030252467، XR_003954297، XR_003954298، XM_036163078 NM_001205313، NM_001205314، NM_009283، XM_017319463، XM_017319464، NM_001357627، XM_030252467، XR_003954297، XR_003954298، XM_036163078
	NP_644671، XP_006712781، XP_016860272 NP_009330، NP_644671، XP_006712781، XP_016860272
	ن/م
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

ترارساننده پیام و فعال‌کنندهٔ رونویسی شماره ۱ (انگلیسی: Signal transducer and activator of transcription 1) یک فاکتور رونویسی است که در انسان توسط ژن «STAT1» کُد می‌شود. این پروتئین یکی از اعضای خانوادهٔ پروتئین STAT است.

این پروتئین در اثر تماس با ملکول‌هایی چون اینترفرون آلفا، اینترفرون گاما، فاکتور رشد اپیدرمی، فاکتور رشد مشتق از پلاکت و اینترلوکین ۶ فعال می‌شود.^[۴]

بین ژنی STAT1 را می‌توان با مادهٔ دی‌آلیل دی‌سولفید (از ترکیبات سیر) تحریک کرد.^[۵]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000026104 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Baris S, Alroqi F, Kiykim A, Karakoc-Aydiner E, Ogulur I, Ozen A, Charbonnier LM, Bakır M, Boztug K, Chatila TA, Barlan IB (October 2016). "Severe Early-Onset Combined Immunodeficiency due to Heterozygous Gain-of-Function Mutations in STAT1". Journal of Clinical Immunology. 36 (7): 641–8. doi:10.1007/s10875-016-0312-3. PMID 27379765.
↑ Lu HF, Yang JS, Lin YT, Tan TW, Ip SW, Li YC, Tsou MF, Chung JG (2007). "Diallyl disulfide induced signal transducer and activator of transcription 1 expression in human colon cancer colo 205 cells using differential display RT-PCR". Cancer Genomics & Proteomics. 4 (2): 93–7. PMID 17804871.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000026104 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-4] Baris S, Alroqi F, Kiykim A, Karakoc-Aydiner E, Ogulur I, Ozen A, Charbonnier LM, Bakır M, Boztug K, Chatila TA, Barlan IB (October 2016). "Severe Early-Onset Combined Immunodeficiency due to Heterozygous Gain-of-Function Mutations in STAT1". Journal of Clinical Immunology. 36 (7): 641–8. doi:10.1007/s10875-016-0312-3. PMID 27379765.

[5] Lu HF, Yang JS, Lin YT, Tan TW, Ip SW, Li YC, Tsou MF, Chung JG (2007). "Diallyl disulfide induced signal transducer and activator of transcription 1 expression in human colon cancer colo 205 cells using differential display RT-PCR". Cancer Genomics & Proteomics. 4 (2): 93–7. PMID 17804871.

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